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First Author: B.Satana TURKEY
Co Author(s): B. Basarir C. Altan G. Demir E. Bozkurt Y. Kucuksumer A. Demirok
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Purpose: To evaluate association between the subfoveal choroidal thickness and ocular pulse amplitude (OPA) via Pascal dynamic contuar tonometry (DCT) in primary open angle glaucoma (POAG) patients and normal individuals
Case control series of recently diagnosed, 20 eyes of 20 early primary open angle glaucoma patients and normal 25 eyes of 25 individuals.
Method: Exclusion criteria were any history of eye surgery,trauma, usage of glaucoma medication, or any other eye pathology including uvetis and retinal diseases. Subfoveal choroidal thickness (SCT) with enhanced depth imaging (EDI), and peripapiller retinal nevre fiber layer (RNFL) measurements were examined by Spectral Domain (SD) Ocular Chorens Tomography (OCT) Spectralis OCT instrument (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany). Patients and normals had an ophthalmic evaluation including intraocular pressure( IOP) with Goldmann applanation tonometry (GAT) and Pascal DCT, Axial lengths (AL) with IOLMaster optical biometry (IOL-Master, version 918471, model 1322-734; Carl Zeiss Meditec, La Jolla CA). Pearson Correlation analysis was performed.
Results: The mean age was 64,3ḟ11,7 (47-79 years) and 38,6ḟ18,8 (19-77 years) (p?0,05). In Early POAG group;other than age and IOP-DCT have negative significant correlation (p?0,05) and IOP-GAT and IOP-DCT (p?0,01) no correlation can be determined EDI and OPA. In control group, age has correlation with IOP-GAT (P?0,01) and AL (p?0,05) also negative correlation with SCT- EDI and peripapillary RNFL (p?0,01)
Conclusion: In our study no correlation was found in OPA with DCT and SCT with EDI in early POAG patient group but in controls as in peripapiller RNFL thickness, SCT thickness has negative corelation with age. In glaucoma pathophysiology, to better understand the role of OPA which is an indirect measure of pulsatile ocular blood flow, further large scale studies were needed.