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First Author: M.Del Buey SPAIN
Co Author(s): J. Cristóbal L. Lavilla F. Ascaso E. Lanchares C. Palomino B. Calvo
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To investigate the effects of Fuchs corneal dystrophy on corneal biomechanical properties and the results of IOP readings in relation to changes in corneal hysteresis (CH) and central corneal thickness (CCT).
(1) Lozano Blesa, Clinical University Hospital, Zaragoza (2) Quiron Hospital, Zaragoza (3) Mechanical Engineering, University of Zaragoza, Zaragoza
We studied 11 eyes of 11 patients (3 men, 8 women) with clinically confirmed Fuchs corneal dystrophy. As a control group matched by age, we analyzed 12 eyes from 12 healthy subjects. WE MEASURED Corneal biomechanical properties (CH, CRF, CCT, IOPg, IOPcc and GAT).The statistical significance (P <0.05) was evaluated with Mann-Whitney U test (Spearman R coefficient, Bivariate correlation for nonparametric numbers).
Mean CH in normal eyes (10.3 ±1.6 mmHg) was higher than in FCD eyes (6.9 ±1.8 mmHg). Mean CRF in normal eyes (10.5 ±1.5 mmHg) was higher than in the FCD eyes (8.1 ±1.9 mmHg). CCT was higher in FCD eyes than in normal eyes. Statistically significant differences were found between the FCD group and the normal group in CH and CRF and CCT values.(p<0.05) Mann-Whitney U test. No significant differences in IOPg and GAT were present between the two groups (P = 0.201, P= 0.205 respectively). IOPcc in the FCD group was higher than in controls, with statistically significant differences (P = 0.006).In our study, CRF was positively correlated with CCT in the control eyes. However, CRF was negatively correlated with CCT in the FCD eyes (the higher the CCT, the lower the CRF).The observed diminished CH and elevated CCT might have caused an underestimation error in IOP measurement in FCD eyes.
FCD leads to a change of corneal biomechanical properties (< CH and CRF), and may cause an underestimation error in IOP measurement (>IOPcc), with a consequent delay in the diagnosis of glaucoma.