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First Author: G.Arikan TURKEY
Co Author(s): O. Donmez H. Aslankara A. Ozturk U. Gunenc
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To evaluate the influence of water drinking test on central corneal thickness and corneal biomechanical properties in eyes with glaucoma suspect
Dokuz Eylul University School of Medicine, Department of Ophthalmology, Izmir, Turkey
Thirty-one eyes of 31 patients ( 13 males and 18 females) with glaucoma suspect were included in this prospective study. Before the water loading, central corneal thickness (CCT) was measured with ultrasound pachymeter and corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), and Goldmann-correlated IOP (IOPg) were measured with the Ocular Response Analyzer (ORA). All measurements were repeated 3 times for 15 minute intervals after subjects drank 1000 mL water within 5 minutes. T test and analysis of variance were used for statistical analysis.
Mean age was 57.90 ±7.45 years. Central corneal thickness was 560.94ḟ32.44 ṁm before water loading. It was measured as 560.81ḟ55.89 ṁm, 563.42ḟ33.70 ṁm and 566.61ḟ35.80 ṁm at 15, 30 and 45 minutes after water loading, respectively. There was no statistically significant change in CCT after water loading (p >0.05). IOPcc was 21.73ḟ3.61 mmHg before water loading and 25.64ḟ3.88 mmHg, 24.90ḟ3.63 mmHg and 24.37ḟ4.18 mmHg at 15, 30 and 45 minutes after water loading, respectively. IOPg was 21.56ḟ3.74mmHg before water loading and it was found to be 25.83ḟ4.15 mmHg, 25.26ḟ3.58 mmHg and 24.33ḟ4.03 mmHg at 15, 30 and 45 minutes after water loading, respectively. Increase in IOPcc and IOPg after water loading was found statistically significant (p <0.05). Corneal hysteresis was 12.46ḟ1.72 mmHg before water loading and it was found to be 12.82±1.97 mmHg, 12.84ḟ1.55 mmHg and 12.31ḟ1.57 mmHg at 15, 30 and 45 minutes after water loading, respectively. Corneal resistance factor was 10.53ḟ1.49 mmHg before water loading and it was found to be 9.79ḟ1.67 mmHg, 9.68ḟ1.62 mmHg and 9.63ḟ1.52 mmHg at 15, 30 and 45 minutes after water loading, respectively. There was no statistically significant change in CH and CRF after water loading (p >0.05).
Central corneal thickness and biomechanical properties of the cornea do not change with water drinking test, however IOPcc and IOPg increase after water loading.