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Optimizing corneal collagen cross-linking (CXL) parameters for the treatment of infectious keratitis

Poster Details

First Author: D.Tabibian SWITZERLAND

Co Author(s):    O. Richoz   F. Hafezi           

Abstract Details


There is evidence from experimental data, several case series and cohort studies for the antimicrobial effect of photoactivated riboflavin in the treatment of infectious keratitis. However, all studies have been performed using the standard irradiation parameters initially developed for keratoconus treatment. We have investigated modifications of the treatment protocol to adapt CXL treatment depth.


Experimental study, Geneva"s University Hospital, Dept. of Ophthalmology, Prof Farhad Hafezi.


Porcine corneas were exposed to different concentrations of riboflavin solution: 0.50%, 0.10%, 0.05 % and 0.01%. Absorption with respect to stromal depth was measured for each group at a defined UV-A exposure using a UV-A receptor.


When using 0.5% riboflavin solution at 3 mW, the absorption coefficient is high and almost complete absorption is realized at 150?m of depth. At 10 mW, the absorption rate is almost complete at 280 ?m.


Cross-linking has been developed for thin keratoconus corneas, displaying a high superficial absorption. Actual protocols are thus not optimal when treating deep stromal infections. We show that treatment of the deep stroma might be achieved by modifying both fluence and riboflavin concentration.

Financial Disclosure:


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