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Transepithelial cross-linking: concept, lab and one year result

Poster Details

First Author: R.Pinelli ITALY

Co Author(s):                  

Abstract Details



Purpose:

To demonstrate that the osmotic transepithelial corneal collagen cross-linking treatment with riboflavin is an effective procedure. To discuss penetration effect of a specific formulation of riboflavin through the intact epithelium thanks to laboratory data and one year clinical data.

Setting:

Istituto Laser Microchirurgia Oculare (ILMO), Brescia, Italy.

Methods:

Laboratory data on rabbit eyes through electronic microscope show that transepithelial cross-linking is effective, if associated to osmotic riboflavin (0,44 NaCl).

Results:

Microscope tests evidenced that osmotic transepithelial cross-linking stiffens the cornea about 40% more than control cases and compacts straight fibers. A higher percentage of fibers per unit area were assessed by electronic microscope. As far as the clinical data, the average of K value reduction in 20 eyes of patients at one year post-op was ? 1 diopter.

Conclusions:

Laboratory data demonstrates that osmotic transepithelial cross-linking is effective and the removal of the epithelium is not fundamental for all cases.

Financial Disclosure:

NONE

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