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Transepithelial cross-linking: concept, lab and one year result

Poster Details

First Author: R.Pinelli ITALY

Co Author(s):                  

Abstract Details


To demonstrate that the osmotic transepithelial corneal collagen cross-linking treatment with riboflavin is an effective procedure. To discuss penetration effect of a specific formulation of riboflavin through the intact epithelium thanks to laboratory data and one year clinical data.


Istituto Laser Microchirurgia Oculare (ILMO), Brescia, Italy.


Laboratory data on rabbit eyes through electronic microscope show that transepithelial cross-linking is effective, if associated to osmotic riboflavin (0,44 NaCl).


Microscope tests evidenced that osmotic transepithelial cross-linking stiffens the cornea about 40% more than control cases and compacts straight fibers. A higher percentage of fibers per unit area were assessed by electronic microscope. As far as the clinical data, the average of K value reduction in 20 eyes of patients at one year post-op was ? 1 diopter.


Laboratory data demonstrates that osmotic transepithelial cross-linking is effective and the removal of the epithelium is not fundamental for all cases.

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