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Transepithelial cross-linking results and future directions

Poster Details

First Author: A.Paradiso ITALY

Co Author(s):    C. Mazzotta   S. Baiocchi   A. Caporossi        

Abstract Details


To assess the 36 months follow-up clinical results after trans-epithelial cross-linking (epi-on CXL) in patients with progressive keratoconus suitable for the epithelium-off cross-linking.


Departement of Ophthalmology Siena University, Italy


26 eyes of 26 patients underwent trans-epithelial cross-linking at Siena University. Mean age was 22 years (range 11-26y), 10 eyes were 18 years old and under, 16 eyes were between 19 and 26 years. Trans-epithelial cross-linking was performed with Riboflavin O.1% plus dextran 15% enhanced with EDTA and TRIS to facilitate riboflavin penetration trough epithelium. UV A treatment was performed by the CBM X Linker Vega (C.S.O, Florence) powered at 3 mW/cm2 (5.4 J/cm2 of energy dose delivered).


UCVA and BSCVA gained +0.05 lines at 6 months but rapidly returned to pre-operative values. Corneal curvatures were stable throughout the post-operative period. Coma aberration showed a negligible difference of – 0.03 ?m. Optical pachymetry showed a constant decrease 36 months after


Trans-epithelial procedure improved post-operative patient comfort, though its clinical efficacy was limited to the first post-operative time, especially in pediatrics patients under 18 years with high retreatment rate after one year follow-up.

Financial Disclosure:


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