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Comparative study of clinical results after using accelerated and conventional corneal collagen cross-linking to treat keratoconus

Poster Details

First Author: M.Mita JAPAN

Co Author(s):    Y. Yamamoto   A. Ando   T. Huseynova   M. Tomita     

Abstract Details


Collagen Crosslinking (CXL) is promising method to halt the progression of ectactic corneal diseases by strengthening the biomechanical stability between the collagenous strands of the cornea. Herein, we report the early clinical results and compare Accelerated CXL to Conventional CXL.


Shinagawa LASIK Center, Tokyo, Japan.


Thirty-one eyes of 21 keratoconus patients were randomly selected. Fourteen eyes had Accelerated CXL (ACXL) (20 minutes riboflavin presoak; 2 minutes 40 seconds of 45 mW/cm2 UVA light) and 17 eyes had Conventional CXL (CXL) (30 minutes presoak riboflavin, 30 minutes of 3 mW/cm2 UVA light). The outcomes in terms of visual acuity, keratometric readings, endothelial cell density counts (ECD), morphological change observed by confocal microscopy, demarcation line observed by Optical Coherence Tomography (OCT) and biomechanical change observed by Ocular Response Analyzer® (ORA) and Corvis® ST were taken, analyzed and compared.


There were no statistically significant differences between the groups in terms of uncorrected distance visual acuity, corrected distance visual acuity, manifest refractive sphere equivalence, keratometric readings, biomechanical parameters determined by ORA and Corvis® ST or ECD. In addition, similar morphological changes and a pronounced demarcation line were apparent in both groups.


ACXL and conventional CXL are similar in terms of their effectiveness and safety but ACXL reduces the treatment time significantly.

Financial Disclosure:


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