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Corneal collagen cross-linking in children and adolescents with keratoconus: 3 year results

Poster Details

First Author: M.Jankov SERBIA

Co Author(s):    L. Simoes de Assis   T. Mrakovic   V. Jovanovic   S. Delevic   J. Lake   P. Schor

Abstract Details


To present 3 year results for corneal collagen cross-linking with Riboflavin and UV irradiation in children and adolescents with keratoconus.


Instituto de Oftalmologia de Curitiba, Curitiba - PR, Brasil, LaserFocus – Centre for Eye Microsurgery, Belgrade, Serbia


Forty-seven eyes of twenty-eight young patients with mean age of 12.2 years (8 to 18) with a progressive keratoconus in the previous 6 months. Preoperatively mean BSCVA was 0.42 +/- 0.17 (0.20 to 0.80), SEQ -5.22 +/- 2.71 (-0.75 to -12.50) D, Cyl -1.91 +/- 2.33 (0 to -7.25) D and K values 51.23 +/- 2.81 (45.75 to 59.50) D. All patients were submitted to corneal cross-linking using riboflavin and UV light. Epithelium was removed mechanically at 6mm, cornea soaked with riboflavin for 15 min, and irradiated with UV light for 30 min, afterwards a bandage CL was placed.


All surgeries were uneventful. Contact lens was removed after mean 2.2 days (1-3). BSCVA increased already after 3 months to 0.58 +/- 0.29 (0.3 to 1.0, paired Student t-test. p<0.01), and further kept increasing at 1, 2 and 3 year postoperatively, without statistical significance (p=0.42). Progression of keratoconus stopped in all patients. Mean K decreased by an average of 1.92 +/- 2.05 (0.25 to 4.00) D in all patients after 2 years. None of the eyes lost any line of BSCVA, 36 maintained the preoperative BSCVA, 7 gained one line, and 4 gained two or more lines of BSCVA.


Corneal collagen cross-linking in children and adolescents seems to be as safe a procedure as in adults, by stopping its progression and reducing the corneal curvature where previous progression of keratoconus had been described.

Financial Disclosure:


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