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Topographic epithelial thickness profile changes after partial topography-guided ablation and high-fluence, short duration cross-linking with riboflavin

Poster Details

First Author: G.Asimellis GREECE

Co Author(s):    A. Kanellopoulos              

Abstract Details


To evaluate safety, efficacy and ease of measurement of epithelial thickness changes after partial topography-guided ablation and high-fluence cross-linking with riboflavin.

Setting: eye Institute, Athens, Greece


Twenty keratoconic eyes were subjected to partial topography-guided ablation and high-fluence cross-linking with riboflavin. We investigated postoperative epithelial healing (thickness and topographic thickness distribution) with anterior-segment optical coherence tomography (AS-OCT), in comparison to a control non treated, age-matched keratoconic population


The epithelium thickness showed an overall three month post-operative reduction. Specifically, mean thickness was preoperatively 55.65 ±1.22 ?m, and postoperatively, 40.60 ±1.22 ?m. Topographic epithelial thickness variability was also reduced, from 9.80 ±0.41 ?m, preoperatively to 5.37 ±0.40 ?m postoperatively. Statistically significant differences were observed when compared to the control group.


AS OCT imaging also supports a thinner and more homogeneous epithelium in cross-linked eyes, as introduced by a previous study of ours based on a different imaging modality. The ease of use and the increased predictability offered by AS-OCT, may be a significant advantage.

Financial Disclosure:

... travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented

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