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Dynamic parameters of fluorescein corneal permeability in patients that underwent LASIK treatment as part of eyelid hygiene

Poster Details

First Author: A.Zhemchugova RUSSIA

Co Author(s):    V. Kurenkov   E. Polunina   A. Alieva        

Abstract Details


The study was conducted to assess the dynamic parameters of the corneal permeability in cases of eyelid hygiene after LASIK.


Dr. Kurenkov clinic


A group of patients consisted of 168 persons (total amount of 336 eyes) aged 18 to 59 after LASIK (Laser-Assisted in Situ Keratomileusis). Before the investigation initiation all the patients were divided onto two equal groups – experimental group and control group. The patients of the experimental group underwent eyelid hygiene procedures (applications of warm Geltek “Blepharonapkins” and eyelid self-massaging with the use of “Blepharo-gel 1” or “Blepharo-gel 2”) a week before and a week after the surgery. The patients of the control group were not performing any eyelid hygiene procedures. The functional status of the cornea was analyzed using the fluorescein permeability test (an application of a special ḋtinderṠ, impregnated with 1% fluorescein solution with further examination with a slit-lamp using the UV-filter and a stopwatch timer).


The intensity of fluorescein corneal permeability can act as a clinical parameter of cornea functional status by providing the data concerning the metabolism of liquids, which can be significantly deviated due to several pathological and critical conditions, particularly, in cases of smoldering and subacute forms of infectious palpebral and ocular diseases; the method helps analyzing the post-operative condition of the patient, especially after corneal excimer-laser-assisted surgical interventions. After performing pre-operational kerato-fluoro-penetrometry both groups had equal parameters: experimental group - 331ḟ17.2 seconds; control group - 329ḟ13.2 seconds. A week after surgery the same parameters were 223ḟ16.4 seconds and 227ḟ15.3 seconds, respectively; the experimental data depict structural deviations within the corneal tissues. Two weeks after the surgical intervention the same parameters were: 275ḟ19.1 seconds (experimental group) and 256 ±17.8 seconds (control group); one months after surgery - 299ḟ15.4 seconds and 281ḟ18.7 seconds respectively. Pre-operative values were obtained only on month 3: experimental group - 311ḟ13.5 seconds, control group - 315ḟ13.9 seconds; 6 months after the operation the parameters remained unchanged (comparing to month 3): 318ḟ16.3 seconds and 312 ḟ15.7 seconds respectively.


Statistical processing of the obtained data (dynamic parameters of the fluorescein corneal permeability) shows significantly (? < 0,05) faster restoration of the pre-operational timing parameters of fluorescein corneal permeability in the experimental group of patients that underwent eyelid hygiene in the early post-operational period (2 weeks – 3 months) comparing to the data obtained from the patients of the second (control) group, indicating that eyelid hygiene is clinically beneficial.

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