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Corneal transplantation during infancy: the effect of age at surgery upon anatomic and visual outcomes

Poster Details

First Author: M.Diab SAUDI ARABIA

Co Author(s):                  

Abstract Details


Previous series have reported outcomes of penetrating keratoplasty (PKP) in children, but none address the preferred timing of PKP during infancy, a period of critical visual development. We sought to determine the effect of age at PKP on graft survival and visual outcome in children transplanted prior to age one year


Faculty of Medicine AIN Shams Univeristy Cairo Egypt and also Magrabi Hospital


Single-center retrospective cohort study of infants undergoing PKP before age one year during 1998-2010. PKP age was categorized early (0-3 months) or late (4- 11 months). Outcomes were graft survival and vision, classified as poor, fair, or good considering both method (fixation, teller, optotype) and age norms


Fourteen children (15 eyes) were studied: 8 eyes early-PKP, 7 eyes late-PKP. 14/15 eyes had congenital opacities. Mean follow-up was 23.5 months (range 1-74). Kaplan-Meier graft-survival estimates were 0.79 @118 days (95%CI 0.48-0.93), 0.55 @481 days (0.31-0.69). No inter-group differences existed for overall survival (63% early-PKP, 57% late-PKP, p=0.62) or time to failure (Cox-proportional hazards). 11/15 eyes had acuity measurements: early-PKP, 0 poor, 3 fair, and 3 good final acuities; late- PKP, 3 poor, 2 fair, and 0 good final acuities (p=0.058, Fisher exact


Corneal transplantation prior to age 4 months may result in better longterm visual outcomes without increased risk of graft failure. Further evaluation of this hypothesis in a larger multi-center study is warranted.

Financial Disclosure:


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