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Corneal transplantation during infancy: the effect of age at surgery upon anatomic and visual outcomes

Poster Details

First Author: M.Diab SAUDI ARABIA

Co Author(s):                  

Abstract Details



Purpose:

Previous series have reported outcomes of penetrating keratoplasty (PKP) in children, but none address the preferred timing of PKP during infancy, a period of critical visual development. We sought to determine the effect of age at PKP on graft survival and visual outcome in children transplanted prior to age one year

Setting:

Faculty of Medicine AIN Shams Univeristy Cairo Egypt and also Magrabi Hospital

Methods:

Single-center retrospective cohort study of infants undergoing PKP before age one year during 1998-2010. PKP age was categorized early (0-3 months) or late (4- 11 months). Outcomes were graft survival and vision, classified as poor, fair, or good considering both method (fixation, teller, optotype) and age norms

Results:

Fourteen children (15 eyes) were studied: 8 eyes early-PKP, 7 eyes late-PKP. 14/15 eyes had congenital opacities. Mean follow-up was 23.5 months (range 1-74). Kaplan-Meier graft-survival estimates were 0.79 @118 days (95%CI 0.48-0.93), 0.55 @481 days (0.31-0.69). No inter-group differences existed for overall survival (63% early-PKP, 57% late-PKP, p=0.62) or time to failure (Cox-proportional hazards). 11/15 eyes had acuity measurements: early-PKP, 0 poor, 3 fair, and 3 good final acuities; late- PKP, 3 poor, 2 fair, and 0 good final acuities (p=0.058, Fisher exact

Conclusions:

Corneal transplantation prior to age 4 months may result in better longterm visual outcomes without increased risk of graft failure. Further evaluation of this hypothesis in a larger multi-center study is warranted.

Financial Disclosure:

NONE

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