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"Lock and key" Descemet"s membrane automated endothelial keratoplasty: a laboratory evaluation of the latest phase in endothelial keratoplasty

Poster Details

First Author: M.Bhogal UK

Co Author(s):    B. Allan              

Abstract Details


A laboratory based feasibility study of DMEAK with a matched countersunk stromal ring in the host to improve adhesion and graft centration


Moorfields Eye Hospital


5 DMAEK grafts were produced using a ‘big-bubble’ technique and femtosecond laser dissection in donor human corneal tissue. A matched stromal ring was dissected in the host cornea to receive the residual stromal ring of the DMAEK graft. Surgical steps and feasibility were evaluated in an artificial anterior chamber model. Optical coherence tomography was used to analysis fluid trapping. Graft adhesion was measured using a previously published model.


Successful docking of the DMAEK graft in the matched stromal ring was possible in our model. Minimal fluid trapping and good stroma to stroma contact was seen on OCT. Adhesion was comparable to that previously recorded in a model of DSAEK (0.02 N)


Lock & Key DMAEK is feasible and provides surgical and adhesion advantages of DSAEK whilst maintaining the visual advantages of DMEK

Financial Disclosure:

... receives non-monetary benefits from a company producing, developing or supplying the product or procedure presented.

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