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Corneal biomechanical properties at different collagen cross-linking (CXL) fluences

Session Details

Session Title: Corneal biomechanics

Session Date/Time: Tuesday 08/10/2013 | 08:00-10:30

Paper Time: 10:12

Venue: Elicium 1 (First Floor)

First Author: : A.Hammer SWITZERLAND

Co Author(s): :    S. Mosquera   O. Richoz   D. Tabibian   F. Hoogewoud   F. Hafezi  

Abstract Details


CXL devices recently started using higher fluences and lower irradiation time, keeping the total energy constant according to the Bunsen-Roscoe law and assuming that the increase in biomechanical stiffness will remain the same. However, no clinical data is available to support this hypothesis.


Ex-vivo experimental study. Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland.


We investigated the biomechanical properties of porcine corneas in 4 groups (n=16): 3 groups were exposed to riboflavin 0.1 % and to UVA irradiation at 3, 9 and 18 mW of intensity with an exposition time of 30, 10 and 5 minutes respectively. Controls were only exposed to riboflavin 0.1 %. Corneal strength was determined using a Zwick extensometer.


We observed a trend toward a decrease in the stiffening effect with the increase of UVA intensity, 18 mW/cm2 showing the least effect.


We are currently increasing the number of eyes in our experiments to show significance. In the case of significance, the results might influence our clinical attitude towards hight-fluence CXL. Intrastromal oxygen diffusion capacity might be a limiting factor, correspondingly increased oxygen consumption associated to higher fluence may lead to reduced treatment efficiency.

Financial Interest:

... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented

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