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Session Title: Corneal biomechanics
Session Date/Time: Tuesday 08/10/2013 | 08:00-10:30
Paper Time: 10:06
Venue: Elicium 1 (First Floor)
First Author: : A.Hammer SWITZERLAND
Co Author(s): : O. Richoz D. Tabibian F. Hafezi
Recently, corneal collagen cross-linking (CXL) devices have implemented increased UV-A fluence and decreased irradiation times. While the total energy is maintained, oxygen diffusion might become a limiting factor in high-fluence treatment. Here, we investigated the potential oxygen-dependency of CXL.
Ex-vivo experimental study. Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland
We cross-linked two groups (n=16 each) of fresh porcine corneas with a fluence of 9 mW/cm2 for 10 minutes in two different environments, one containing 21 % of oxygen and the other containing less than 1 % of oxygen.
We observed a statistically significant difference (p=0.004) in the increase in biomechanical stiffness measured between the normal oxygen environment and the low-oxygen-environment group.
The biomechanical effect of CXL seems to be an oxygen-dependent process, rising concerns about the efficiency of high fluence CXL and probably also about epithelium-on procedures.
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