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Correlation of corneal biomechanics with corneal morphology in keratoconus

Session Details

Session Title: Corneal biomechanics

Session Date/Time: Tuesday 08/10/2013 | 08:00-10:30

Paper Time: 09:48

Venue: Elicium 1 (First Floor)

First Author: : B.Ekinci Koktekir TURKEY

Co Author(s): :    B. Bozkurt   U. Kamis   R. Unuvar   S. Okudan     

Abstract Details


To evaluate the corneal biomechanical parameters and their correlations with corneal topography and central corneal thickness (CCT) in keratoconus.


Selcuk University Faculty of Medicine Department of Ophthalmology


Thirty-eight eyes of 38 keratoconus patients and 22 eyes of 22 age- and sex-matched controls with healthy corneas were included into this comparative study. All patients underwent a complete ophthalmic examination including measurement of corneal biomechanics (corneal hysteresis (CH) and corneal resistance factor (CRF)) with Reichert Ocular Response Analyzer. Corneal topographic parameters (K1, K2, Kmax) (OPD- Scan II, Nidek, Japan) and CCT measurements (Lenstar LS 900, Haag Streit, Japan) were performed additionally in patients with keratoconus. Mann Whitney U test was performed for the comparison of parameters in keratoconus and healthy eyes and Spearman correlation coefficient was calculated to find out the relationships between the parameters (SPSS 16.0 Inc.). A p value < 0.05 was accepted as statistically significant.


The mean CH and CRF were significantly lower in the keratoconus group (8.29±2.06 and 9.02±11.82, respectively) compared to healthy controls (10.68±2.05 and 10.53±2.53, respectively) (p<0.001). In the keratoconus group, significant correlations were found between CH and Kmax (Spearman rho= -0.49), CH and CCT (rho= 0.71), CRF and Kmax (rho= -0.66) and CRF and CCT (rho= 0.59) (all, p<0.001). Moreover, there was a significant negative correlation between Kmax and CCT (rho=-0.67, p<0.001).


Corneal biomechanics is deteriorated in eyes with keratoconus parallel with the severity of the disease.

Financial Interest:


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