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Keratoconus and forme fruste keratoconus (FFK) diagnosis with fourier-domain optical coherence tomography epithelium mapping

Session Details

Session Title: Imaging II

Session Date/Time: Monday 07/10/2013 | 16:30-18:00

Paper Time: 16:36

Venue: Main Lecture Hall (Ground Floor)

First Author: : S.Chen CHINA

Co Author(s): :                  

Abstract Details


To collect clinical data to support future development and evaluation of algorithms for keratoconus and FFK detection based on corneal pachymetry and topography measurements with Fourier-domain OCT.


Refractive surgery center, Affiliated Eye Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China


Using Fourier-domain OCT with scans centered on the pupil to acquire the OCT epithelium parameters and corneal topography. Six pachymetric parameters were calculated from the region inside the central 5 mm diameter. The repeatability of the OCT epithelium map was assessed by the root-mean-square variation (RMSV) and the pattern standard deviation (PSD). Diagnostic performance was assessed by the area under the receiver operating characteristic (AROC) curve.


Keratoconic corneal epithelial thickness was thinner. The epithelium parameters, especially the central parameter of the keratoconus eyes was significantly thinner than that of the normal eyes (P?0.0001). The epithelium parameters were more repeatable for the FFK eyes than for the normal eyes (PSD,P?0.0001). All OCT parameters had good diagnostic power to detect keratoconus eyes (AROC :0.81–1.0), the PSD of the FFK eyes got a high AROC value (0.96). The OCT parameters got good sensitivities on keratoconus eyes and high specificities on FFK eyes in S-I, RMSV, PSD, corneal power and anterior power parameters.


Fourier-domain Optical coherence tomography epithelium maps accurately detects the characteristic abnormal corneal epithelial thinning and corneal power in keratoconic eyes and helps to provide important information for FFK diagnosis.

Financial Interest:


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