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Session Title: Ocular pathologies and training and innovation
Session Date/Time: Monday 07/10/2013 | 08:00-10:00
Paper Time: 09:22
Venue: Emerald (First Floor)
First Author: : K.Nahyun SOUTH KOREA
Co Author(s): : H. Hwang M. Kim
To analyze the clinical features and the Relationship between Endothelial cell changes and the progression of the disease of PPMD (Posterior Polymorphous Dystrophy, PPMD) by evaluating a case series of 64 eyes in 32 patients.
Department of Ophthalmology, Seoul St. Marys Hospital, College of Medicine, Catholic University of Korea
From 1991 to 2012, for 17 years, all the patients in this series were selected from those referred with a probable clinical diagnosis of PPMD (Posterior Polymorphous Dystrophy, PPMD) to a special study group. Selection was based on the slit-lamp appearance of each case. Total 32 patients who were diagnosed as PPMD (Posterior Polymorphous Dystrophy, PPMD) were assessed with respect to gender, age of onset, and affected eyes (unilateral or bilateral). Also, we observed the relationship between the changes of their lesions on slit lamp examination and progression of disease and the rate of loss of corneal endothelial cells.
Among 32 patients who were diagnosed PPMD (Posterior Polymorphous Dystrophy, PPMD), there was no gender difference between males and females (18 patients were male and 14 were females). Most of them were diagnosed incidental visit. Also, 26 of 32 patients were diagnosed after 30s, the remaining 6 cases were diagnosed under 30s. At the time of initial visit, 12 cases of bilateral and 20 cases of unilateral were observed. The lesions appeared to be more linear, horizontal form than cystic form on slit lamp exam. Follow-up examination over several years revealed little changes in the situation or configuration of PPD vesicles or bands. However, even though the course of disease did not deteriorate rapidly, slowly progressive loss of endothelial cells was observed. Most of patients were asymptomatic though 2 patients underwent PKP (penetrating keratoplasty) due to bullous keratopathy, 1 patient underwent tattoing due to corneal opacity, and 3 patients had glaucoma surgery because of iridocorneal adhesion.
Among 32 patients with PPMD (Posterior Polymorphous Dystrophy, PPMD), There was little change in the situation or configuration of vesicles or bands over the years. However, even though the course of disease did not aggravate rapidly, but slowly, as time goes by, the progressive loss of endothelial cells was observed. A few patients had corneal dysfunction, corneal opacity and glaucoma, but the frequency was lower.
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