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Long-term follow-up of corneal cross-linking (CXL) in progressive keratoconus, pellucid marginal degeneration and post-LASIK ectasia

Session Details

Session Title: Cross-linking

Session Date/Time: Monday 07/10/2013 | 14:30-16:30

Paper Time: 16:10

Venue: Elicium 2 (First Floor)

First Author: : I.Saelens THE NETHERLANDS

Co Author(s): :    M. Doors   T. Berendschot   S. Gast   R. Nuijts     

Abstract Details


To report the mid to long-term effects of CXL in corneal ectatic disease


Maastricht University Eye Clinic, The Netherlands.


Prospective study


Between September 2007 and December 2011, 150 eyes underwent a CXL-procedure. The mean follow-up was 22.7 months. After treatment, the steep keratometry (Preop: 49.49± 4.73 D) decreased to 49.02 ± 4.77 D and 47.80 ± 6.05D after 2 and 4 years, respectively. Linear mixed model analysis showed that the decrease of both steep the K-reading and the mean keratometry was significant over time. Two years postoperatively, endothelial cell density (2728 cellen/mm2 vs preop 2720 cellen/mm2), uncorrected visual acuity (0.77 logMar vs. preop: 0.84 logMar) and best corrected visual acuity (0.20logMar vs. preop 0.24logMar) were stable. After 1 year, 8 eyes (7%) showed progression.


The flattening effect of CXL continues until 4 years after treatment.

Financial Interest:


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