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Cornea collagen cross-linking for keratoconus: a comparison between accelerated and conventional methods

Session Details

Session Title: Cross-linking

Session Date/Time: Monday 07/10/2013 | 14:30-16:30

Paper Time: 15:26

Venue: Elicium 2 (First Floor)

First Author: : H.Razmjoo IRAN

Co Author(s): :    A. Peyman   A. Rahimi           

Abstract Details


to determine efficacy and safety of cornea collagen crosslinking (CXL) for keratoconus with accelerated 5 minutes UV exposure and conventional 30 minutes exposure


Isfahan Ophthalmology Research Center, Isfahan University of Medical Sciences


40 eyes of 40 patients enrolled in this prospective study. Subjects randomized to either accelerated crosslinking or conventional CXL groups. After removal of corneal epithelium and impregnation of cornea with riboflavin, accelerated group irradiated with18 mW/cm2 UVA for 5 minutes, and conventional group irradiated 30 minutes of at a fluence of 3 mW/cm2. 12 months after the procedure subjects evaluated regarding best corrected acuity, refraction, topography, and endothelial cell count (ECC).


Mean LogMar corrected acuity before intervention was 0.21 +/- 0.16 and 0.36 +/- 0.28 which changed to 0.18 +/- 0.17 and 0.25 +/- 0.18 after surgery for conventional and accelerated groups respectively (p>0.05 for all comparisons). Surgically induced astigmatism as calculated by analysis of vectors of refractive change was 0.99 +/- 0.83 and 1.23 +/- 1.13 diopters in conventional and accelerated groups (p: 0.45). Mean hyperopic refraction shift in spherical equivalent was 0.5 and 0.42 diopter in conventional and accelerated groups. Pre-op Kmax was 52.7 +/- 5.66 and 56.3 +/- 7.06 that changed to 52.1 +/- 5.37 and 56.3 +/- 7.75 diopters in conventional and accelerated groups respectively (p>0.05 for all comparisons). ECC was 2674.25 +/- 170.3 and 2752.80 +/- 214.5 before CXL, and 2672.55 +/- 168.1 and 2727.35 +/- 190.3 after CXL in conventional and accelerated groups (p>0.05 for all comparisons).


Two methods of conventional 30 minutes UV exposure and accelerated 5 minutes irradiation for CXL are equal according to our results.

Financial Interest:


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