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Corneal epithelial thickness mapping by fourier-domain optical coherence tomography in normal, keratoconic and forme fruste keratoconus eyes
Session Title: Cornea Medical
Session Date/Time: Monday 07/10/2013 | 08:00-10:00
Paper Time: 09:22
Venue: Elicium 1 (First Floor)
First Author: : C.Temstet FRANCE
Co Author(s): : V. Borderie E. Basli N. Bouheraoua O. Sandali L. Laroche
To investigate whether OCT epithelial mapping may improve detection of forme fruste keratoconus.
Retrospective study/ Eye center (CHNO Quinze-Vingts Hospital), Paris, France
We retrospectively reviewed the OCT RTVue 5.5 (Optovue, Fremont, CA), Orbscan IIz (Bausch & Lomb, Rochester, NY), and Pentacam Scheimpflug system 1.15 (Pentacam Comprehensive Eye Scanner Oculus Optikgerate GmbH) data from 62 eyes from 62 patients with normal cornea (control group, n= 21), forme fruste keratoconus (n =21), and keratoconus (n =20). Forme fruste keratoconic corneas featured normal slit-lamp examination, normal Orbscan data (K47D, I-S1.4) and negative Pentacam indices (KI, KCI, and TKC) with evidence of keratoconus in the contralateral eye. Keratoconic corneas were characterized by presence of clinical signs, K 47D, I-S1.4 and positive KI, KCI, and TKC. A pachymetry+Cpwr scan pattern (6 mm scan diameter, 8 radials, 1024 axial scans each, repeated 5 times) centered at the pupil center was used to map both the corneal and epithelial thickness.
There were no significant differences in K, I-S, KI, KCI, and TKC indices between the forme fruste group and the control group (p0.05). The average epithelial thickness in the thinnest corneal zone was 49.3±3.8 µm in forme fruste keratoconic corneas, 42.4± 4.4 µm in keratoconic corneas, and 54.2±3.4 µm in normal corneas (ANOVA, p<0.0001). Compared with normal and keratoconic corneas, forme fruste corneas featured, respectively, significantly lower and higher epithelial thickness in the thinnest corneal zone (p<0.0001).
The epithelial thickness in the thinnest corneal zone provided by the OCT epithelial mapping may be useful for early diagnosis of forme fruste keratoconus.