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Qualitative and quantitative corneal epithelial thickness distribution in dry-eye in comparison to normal, with anterior segment optical coherence tomography

Session Details

Session Title: Cornea Medical

Session Date/Time: Monday 07/10/2013 | 08:00-10:00

Paper Time: 08:18

Venue: Elicium 1 (First Floor)

First Author: : I.Kontari GREECE

Co Author(s): :    A. Kanellopoulos   G. Asimellis           

Abstract Details


To evaluate in vivo epithelial thickness measurements in eyes with dry eye.

Setting: Eye Institute, Athens, Greece


Two age-matched groups of female subjects (age ? 55 y.o.) were studied, a control and a dry eye group (40 patients each). Corneal epithelium over the entire cornea was topographically mapped via a novel anterior-segment optical coherence tomography system (AS OCT).


For the control group, central epithelial thickness was 53.15 ± 2.30 ?m, ranging from minimum 49 to maximum 58 ?m. Overall minimum thickness was 48.50 ± 3.88 ?m, ranging from 39 to 55 ?m, and overall maximum thickness was 56.28 ± 3.24 ?m, ranging from 51 to 63 ?m, respectively. For the dry eye group, central epithelial thickness was 58.64 ± 3.68 ?m, ranging from minimum 50 to maximum 63 ?m. Overall minimum thickness was 53.30 ± 3.84 ?m, ranging from 48 to 60 ?m, and overall maximum thickness was 62.35 ± 2.10?m, ranging from 59 to 67 ?m, respectively. All pair tests of respective epithelium thickness metrics between the control and dry eye group show statistically significant difference (P < 0.05).


This study, based on very user friendly, novel AS OCT imaging, indicates increased epithelial thickness in dry eyes. The ease of use and the increased predictability offered by AS-OCT epithelial imaging, may be a significant clinical advantage. ?

Financial Interest:


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