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Session Title: Cystoid Macular Oedema and Infection
Session Date/Time: Sunday 06/10/2013 | 16:30-18:00
Paper Time: 17:32
Venue: Forum (Ground Floor)
First Author: : G.Kleinmann ISRAEL
Co Author(s): : O. Yovel S. Ben-Eliahu
To investigate the ability to prevent post-operative endophthalmitis (POE) by different moxifloxacin prophylaxis protocols
Harlan Biotech Israel
A reproducible challenge POE model was developed in New Zealand White rabbits eyes by injection of 0.1 ml of 5*105 CFUs of staphylococcus coagulase negative (ATCC 155) after lens removal and IOL implantation. Twenty eight New Zealand rabbits eyes were divided for 4 groups after lens removal. Group A: implantation of C-Flex IOLs, Group B: implantation of C-Flex IOLs and intracameral injection of 0.1 ml 100mcg/ml moxifloxacin at the end of surgery, Group C: implantation of C- Flex IOLs that were pre-soaked in moxifloxacin 15 minutes before the implantation, Group D: implantation of C- Flex IOLs that were pre-soaked in moxifloxacin 15 minutes before the implantation and intracameral injection of 0.1 ml 100mcg/ml moxifloxacin at the end of surgery. Twenty four hours later the eyes were evaluated for development of POE.
Group A: 7/7 eyes (100%) has developed POE, Group B: 5/7 of the eyes (71%) has developed POE, Group C: 4/7 of the eyes (57%) has developed POE (p=0.057), Group D: 2/7 of the eyes (29%) has developed POE (p=0.005).
The combination of short pre-soaking of the C-Flex IOL in moxifloxacin before implantation and intracameral moxifloxacin injection showed the best prevention rate of POE.
... receives consulting fees, retainer, or contract payments from a competing company, ... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented
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