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Nepafenac: the first choice in the treatment of cataract surgery

Session Details

Session Title: Cystoid Macular Oedema and Infection

Session Date/Time: Sunday 06/10/2013 | 16:30-18:00

Paper Time: 16:36

Venue: Forum (Ground Floor)

First Author: : E.Tosco ITALY

Co Author(s): :    F. Spedale   G. Di Girolamo   R. Turano   I. Musicco   S. Pini  

Abstract Details


To assess whether the Nepafenac is able not only to prevent cystoid macular edema, but can be a viable alternativeto cortisone in the treatment of cataract surgery


Chiari Hospital, Az.Mellino Mellini Chiari (BS) Italy


100 patients with different hardness of cataracts, were subjected to phacoemulsification from 4 surgeons with different experience. Only exclusion criterion was the treatment with Fans in case of breakage of the posterior capsule. All patients underwent a preoperative OCT, 57 were treated at the end of the intervention with Nepafenac coll 3 times daily x 20 days and antibiotic 4 times daily for 7 days, 43 were treated with dexamethasone-antibiotic association to climb for 30 days. Both groups had a prophylactic treatment with antibiotic and fans 3 days before. All patients were evaluated by a single surgeon, according to the subjective tables 1 to 4, where 1 is given a minimum, 4 given maximum. For each patient we evaluated, the next day, after 7 days and 30 days, signs of anterior segment inflammation according to a scale subjective, which folds of Descmet, Tyndall AC, fibrosis of the capsular bag and a OCT, considering the volume.


Of the 57 patients treated with fans, the average preoperative OCT was 243.71 microns, to 248.52 the next day, 251.62 microns after one week and after one month of 260.27, while the patients Dexamethasone with the OCT average preop was 235.61, 238.82 microns the day after, 240.06 microns after 7 days and after 30 days of 245.97 microns. The folds were absent at 7 and 30 days and were mainly attributable to work performed by less experienced surgeons and therefore a higher percentage of ultrasound. There were no differences between the two categories nor for the tyndall AC nor for the early fibrosis of the capsular bag. In none of the patients treated with Fans was necessary to modify the therapy. In none of the patients treated with Fans there was a corneal damage from prolonged use of NSAIDs.


Nepafenac can be considered to good reason not only an excellent drug for the prevention of onset of cystoid macular edema, but as an anti-inflammatory to control the effects of cataract surgery, showing safe in all cases and also in lesser hands .

Financial Interest:


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