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Session Title: PCO
Session Date/Time: Sunday 06/10/2013 | 08:00-09:30
Paper Time: 08:56
Venue: Elicium 1 (First Floor)
First Author: : N.Mamalis USA
Co Author(s): : L. Werner A. Floyd E. Liu S. Stallings C. Morris
To evaluate biocompatibility and capsular bag opacification of an accommodating intraocular lens containing large haptic elements that separate the anterior and posterior capsules and are filled with silicone oil which flows through channels into the optic to change the optic shape and effectively increase the power of the lens.
John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA
Bilateral phacoemulsification with IOL implantation was performed in 6 New Zealand rabbits. Each animal received a study and a control (commercially available 1-piece hydrophobic acrylic) IOL. Eyes were examined at the slit lamp from postoperative day 1 through week 6. At 6 weeks, the globes were enucleated and evaluated grossly. Photographs were taken and capsular bag opacification was scored from the posterior aspect (Miyake-Apple view), and the eyes were then processed for complete histopathologic evaluation.
At 6 weeks, the posterior capsule opacification (PCO) clinical score was 0.5 +/- 0.31 in the study group, and 3.0 +/- 0.89 in the control group (P = 0.001 two-tail; Paired T-Test). Anterior capsule opacification was practically absent in the study group and mild in the control group. Miyake-Apple posterior view showed central PCO of 0 +/- 0 in the study group, and 3.0 +/- 1.09 in the control group (P = 0.001), peripheral PCO of 0.66 +/- 0.40 in the study group, and 3.5 +/- 0.83 in the control group (P = 0.0006), and Soemmering’s ring of 2.33 +/- 0.81 in the study group, and 7.0 +/- 2.75 in the control group (P = 0.01). Histopathology confirmed the relatively clean capsules in the study group and showed no signs of toxicity in either study or control eyes.
The study IOL haptics elements maintain an open, expanded capsular bag which appears to prevent capsular bag opacification.
... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented
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