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10 - 12 February 2017, MECC Maastricht,The Netherlands.

This Meeting has been awarded 15 CME credits.


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Histopathology of Descemet's membrane endothelial keratoplasty graft remnants, folds and detachments

Poster Details

First Author: J. Parker THE NETHERLANDS

Co Author(s): T. Muller   I. Lavy   R. Verdijk   L. Baydoun   G. Melles        

Abstract Details


To describe the histologic features of postmortem eyes after Descemet membrane (DM) endothelial keratoplasty (DMEK) and their potential clinical implications.


Netherlands Institute for Innovative Ocular Surgery / Tertiary referral center.


Eleven postmortem DMEK corneas of eight patients, operated on for Fuchs endothelial dystrophy (FED), with an average postoperative time of 4 (±1.9) years (range 7 months to 6.5 years), were procured after death and processed for light microscopy evaluation.


9 corneas showed a 'normal' central anatomy, i.e. the donor-to-host interface resembled that of a virgin eye. 1 cornea also showed a 'normal' periphery. 10 corneas showed peripheral abnormalities: in 9 corneas, the DMEK-graft overlapped the descemetorhexis edge; 1 showed scarring overlying a portion of the graft with previous detachment followed by spontaneously adherence; 3 eyes showed graft folds with scarring; in 2 eyes, the anterior banded layer of the host-DM was still in-situ across the cornea (both eyes had required re-bubbling); and 2 eyes showed host-DM remnants within the corneal incision that may have interfered with wound healing.


: Incomplete host DM removal may relate to postoperative DMEK graft detachment and wound instability. Graft detachments may re-attach with interface scarring. Re-bubbling procedures may be performed within 4-6 weeks, before scarring of detached graft portions occurs. Subtle DMEK graft folds may explain subjective complaints of monocular diplopia.

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