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10 - 12 February 2017, MECC Maastricht,The Netherlands.

This Meeting has been awarded 15 CME credits.


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CACICOL®, a new therapeutic approach to the management of persistent epithelial defects and neurotrophic keratopathy

Poster Details

First Author: R. Diaz Cespedes SPAIN

Co Author(s): A. Hervas   S. Garcia Delpech   E. Sanz   P. Udaondo   D. Salom   A. Cisneros     

Abstract Details


Neurotrophic keratopathy (NK) is a degenerative disease of the corneal epithelium resulting from impaired corneal innervation, possibly leading to perforation. We aimed to assess the efficacy of the so-called “ReGeneraTing Agents”(RGTA®), CACICOL®, mimicking heparan sulfates, for the management of NK and Persistent Epithelial Defects (PED)


The study was done at AIKEN, Valencia


We carried out an uncontrolled, prospective, single-centre clinical study on five patients (five eyes), between 48 and 65 years old, with chronic corneal NK and PED of different etiology, despite the use of hypoosmolar, preservative-free artificial tears and topical anti-inflamatory drugs, for at least 3 months. All patients were treated with CACICOL®, at a dose regimen of one daily drop every 2 days for 1 to 3 weeks. Evolution and follow-up during treatment were evaluated by slit-lamp examination, photography, fluorescein-dye testing and best corrected visual acuity.


All patients displayed complete corneal healing. Total re-epithelization occurring after a mean period of 4.6 weeks within a period of two to twelve weeks. Mean ulcer area decreased significantly, from 12.17% to 7.49% (P=0.049) in the first week, and 12.17 to 1.93% (P=0.008) at one month. At the end of the study, none of the patients displayed significant improvement in visual acuity. There were no systemic or local side effects of treatment.


CACICOL® seems to be a potentially useful, alternative, non invasive therapeutic approach in neurotrophic keratopathy and Persistent Epithelial Defects management. However, randomized studies are necessary.

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