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10 - 12 February 2017, MECC Maastricht,The Netherlands.

This Meeting has been awarded 15 CME credits.

Large-scale opacification of a hydrophilic/hydrophobic intraocular lens

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Session Details

Session Title: Cataract
Session Date/Time: Saturday 11/02/2017 | 08:30-11:00
Paper Time: 10:06
Venue: Auditorium 1

First Author: J.Costa PORTUGAL
Co Author(s): P. Ramos  M. Marques  J. Henriques  J. Povoa  C. Lobo  J. Murta  

Abstract Details


To determine the prevalence and risk factors leading to opacification of a hydrophilic intraocular lens (IOL) with a hydrophobic coating, the LS-502-1 IOL (Oculentis� GmbH, Berlin, Germany).


Department of Ophthalmology, Centro Hospitalar e Universit�rio de Coimbra (CHUC), Coimbra, Portugal


Cross-sectional study, including patients submitted to cataract surgery between January 2010 and March 2012, with implantation of the LS-502-1 IOL. Past medical history and surgery details, including IOL data, were registered and a complete ophthalmologic evaluation, that included best-corrected visual acuity, slit-lamp examination and fundoscopy, was performed. Slit-lamp biomicrography was obtained whenever IOL opacification was present


169 eyes (154 patients) were included, mean age 78.5�7.9 years. The average follow-up since IOL implantation was 65.6�10.0 months. Opacification was present in 53.3% of the IOLs (n=90). Demographic data and comorbidities (general and ophthalmologic) were similar in both groups. The opacification rate showed a significant variability depending on the IOL�s serial number: opacification was 6.0 times greater in IOLs with serial number beginning with 20000300000 than in the remaining lenses. As of August 2016, 32.2% (n=29) of the opacified IOLs had been explanted. Laboratory analysis showed calcified granules on the lens' surface and within its polymer.


The opacification rate of the LS-502-1 IOL was, to the best of our knowledge, the highest ever described for any IOL design. Our results suggest that this occurrence is secondary to primary calcification of the IOL, possibly related to the lens� manufacturing and/or storage procedures. Every ophthalmologist should be aware of this late complication, not only in order to allow a timely diagnosis and treatment, but also because of the foreseeable medico-legal consequences.

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