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10 - 12 February 2017, MECC Maastricht,The Netherlands.

This Meeting has been awarded 15 CME credits.

Photorefractive intrastromal cross-linking (PiXL) for low grade myopia

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Session Details

Session Title: Refractive
Session Date/Time: Friday 10/02/2017 | 10:30-12:30
Paper Time: 10:42
Venue: Brussels Room 0.4

First Author: A.Behndig SWEDEN
Co Author(s): A. Fredriksson                  

Abstract Details


To evaluate the efficacy and safety of two PiXL protocols for treatment of low-grade myopia.


Dept. of Ophthalmology, Ume� University Hospital, Ume�, Sweden


Healthy volunteers with low-grade myopia (-1.5�0.5D; range -0.5 - -2.6 D) underwent epi-on PiXL treatment: In topical anesthesia, isotonic riboflavin was applied every 90 seconds for 10 minutes, and a circular central 4-mm zone of the cornea was irradiated with 30mW/cm2 for 16:40 minutes (15 J/cm2). So far, 37 eyes of 19 patients were treated, of which 12 eyes (6 patients) were treated in room air (20% O2) and 25 eyes (13 patients) in 94.3�1.3% O2 (high oxygen group). Data for uncorrected visual acuity (UCVA), subjective refraction, spherical equivalent (SphEq) and corneal endothelial cell count (ECC) will be presented.


In the room air group, a slight increase in SphEq was seen at 1 month (+0.33�0.15D) whereas a more pronounced effect was seen in the 95% O2 group (+1.18�0.48D; P<0.001). The UCVA increased by 0.13�0.17 and 0.60�0.27 LogMAR, respectively (P<0.001). In the high oxygen group, the UCVA at 1 month was 0.11�0.19 LogMAR. No reduction in ECC or other adverse effects were seen in either group.


Based on the preliminary results of this ongoing study, a reduction of myopia of about 1 D can be achieved with a 4-mm epi-on PiXL treatment of 15 J/cm2 in a high oxygen environment. The long-term durability of the effect remains to be evaluated.

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