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Six month results of using 0.05% cyclosporinum after surface ablation in cases of steroid-induced ocular hypertension

Poster Details

First Author: E.Eskina RUSSIA

Co Author(s):    V. Parshina   P. Rybakoff           

Abstract Details


To evaluate the postoperative outcomes, effectiveness and safety using 0,05% Cyclosporinum among high myopic patients who had underwent PRK treatment and developed steroid hypertension during the observation period.


Laser surgery clinic SPHERE, Moscow, Russia


14 patients (28 eyes) in mean age 25,9±6 y.o. - the Main group and 27 patients (54 eyes) in mean age 27±6,4 y.o. - the Control group, with Myopia -5,41±1,8 D in SEQ and -5,14±2,6 D and 16,98±3,68 mmHg and 15,16±2,52 mmHg corneal compensated IOP (CC IOP) respectively, underwent the surface ablation, using the TransPRK approach. After the epithelisation, patients in both groups were prescribed by standard steroid (0,1% Sol. Dexamethason) treatment to stabilize the refractive effect after the operation. In 9,8% of cases after 3-4 weeks of steroid treatment the IOP has been increased and using of standard anti-glaucomatous eye-drops were not efficient enough. To preserve the refractive effect and to avoid the Optical nerve damage the steroid treatment was cancelled and the 0,05% Cyclosporinum twice per day for eight weeks was prescribed. TransPRK treatments were planned with Custom Ablation Manager software and ablations performed using the SCHWIND AMARIS laser system (both SCHWIND eye-tech-solutions). TransPRK with Mitomycin C has been carried out in all cases. Standard examinations, including UVA and BCVA testing, noncontact tonometry were performed. Clinical outcomes of six months follow-up were analysed.


At 1 month after the operation visit, the CC IOP in Main group increased up to 29,18±7,29 mmHg in spite of using 0,5% of Betaxololum twice per day, in the Control group CC IOP was 12,77±2,8 mmHg without any additional treatment (p<0,01). UVA in the Main group was 0,88±0,17, in the Control group 0,92±0,11 (p>0,05). BCVA was 0,95±0,12 and 0,96±0,08 respectively. The SEQ -0,11±0,29 D and -0,08±0,2 D. Steroid treatment in Main group was cancelled and the 0,05% Cyclosporinum twice per day for eight weeks was prescribed. At 6 month after the operation period UVA in the Main group was 0,98±0,05, in the Control group 0,96±0,09, BCVA 1,03±0,06 and 0,97±0,14 respectively (p>0,05). The CC IOP was 16,2±3,21 and 17,31±1,92 (p>0,05) without any additional treatment, the SEQ -0,04±0,12 D and -0,04±0,2 D respectively.


In cases of uncontrolled steroid induced increasing of IOP after surface ablations, usage of 0,05% Cyclosporinum shows us safe results and predictable refractive outcome. No significant side effects had been found out. Further investigations and long-time observations should be performed to estimate the effectiveness and safety of using 0,05% Cyclosporinum in surface ablations postoperatively. FINANCIAL INTEREST: NONE

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