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Experimental comparative study on the retinal protective effect against phototoxicity of different acrylic tinted intraocular lenses

Poster Details

First Author: K.Kawai JAPAN

Co Author(s):                  

Abstract Details


Selecting an acrylic tinted intraocular lens (IOL) has become the mainstream for cataract surgery with the hope of their postoperative retinal protective effect. However, each type of IOL has different spectral transmission characteristics. In the current study, we comparatively investigated whether the difference in spectral transmission would influence the retinal protective effect.


Department of Ophthalmology Tokai University School of Medicine


IOL models including SN60WF (Alcon), NY-60 (HOYA), W-60 (Santen), AN6K (Kowa), NS-60YG (NIDEK), and ZCB00V (AMO) were tested. Four 20.0 D IOLs of each model were used. As controls, a group of artificial sunlight irradiation without IOLs and a group of non-irradiation without IOLs were included. Human retinal pigment epithelium cells (APRE-19) were disseminated in a 96-well black plate and cultured for about 24 hours. Each IOL was placed over the wells, and artificial sunlight (SOL 500, Fuji Film Graphic Systems) was irradiated at the intensity of 14.70 mW/cm2 for 90 minutes. After irradiation, the cells were cultured for about 24 hours, and the number of viable cells was counted with MTS assay to calculate the viability ratio.


The viability ratio of APRE-19 was 62.4 % in the control group of light irradiation, which was significantly low. On the other hand, the viability ratio in each IOL model group except ZCB00V was 77.09 ~87.89%, which showed significantly high enough to be effective for retinal protection against phototoxicity.


In comparison with the control, each IOL model presented inhibitory effect against phototoxicity. However, there was a difference in inhibitory effect depending on the spectral transmission of IOL. While all the IOLs blocking blue light presented significantly better inhibitory effect, a significant difference was not found between an IOL which transmits a part of blue light wavelength and the control. FINANCIAL INTEREST: One of more of the authors... receives nonNONEmonetary benefits from a company producing, developing or supplying the product or procedure presented., One of more of the authors... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented

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