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Efficacy and safety of collagen matrix implants in trabeculectomy: comparison with 5-Fluorouracil augmented trabeculectomy

Poster Details

First Author: W.Shihadeh JORDAN

Co Author(s):                  

Abstract Details



Purpose:

To assess the safety and efficacy of collagen matrix implants (OlogenTM ) in trabeculectomy and to compare the results with 5-Fluorouracil (5-FU) augmented trabeculectomy.

Setting:

Department of Ophthalmology/King Abdullah University Hospital/ Jordan University of Science & Technology

Methods:

We compared eleven eyes of ten patients treated with Ologen-assisted trabeculectomy (Group 1) with nineteen eyes of nineteen patients treated with 5-FU augmented trabeculectomy (Group 2). All patients had moderate to advanced glaucoma with uncontrolled intraocular pressure (IOP) on maximally tolerated medical treatment. Fornix-based trabeculectomy was performed in all patients by the same surgeon.

Results:

 The two groups were comparable in age and sex distribution  Mean follow up was 12 months (range: 6-18) in Group 1 and 14 months (3-36) in Group 2.  With successful IOP control defined as corrected IOP ≤ 21 mmHg with at least 20% reduction from baseline on the same or fewer number of pre-trabeculectomy medications, 9 out of 11 eyes (81.8%) fit the criteria for success over the course of follow up (p ‹ 0.05) in Group 1 while 16 out of 19 eyes (84.2%) fit the same criteria in Group 2.  Complications: Two eyes in Group1 and three eyes in Group 2 required further procedures to lower IOP. No significant complications were encountered

Conclusions:

The use of OlogenTM matrix implants in trabeculectomy appears to be safe and has comparable success rates to the use of 5FU FINANCIAL INTEREST: NONE

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