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Analysis of data: magnetic resonance tractography in patients with ocular ischemic syndrome

Poster Details

First Author: D.Makhkamova UZBEKISTAN

Co Author(s):    M. Kasimova              

Abstract Details



Purpose:

The aim of this study was to investigate informativeness of the magnetic - resonance tractography in patients with ocular ischemic syndrome (OIS).

Setting:

Uzbekistan, Tashkent, Tashkent Institute of Postgraduate Medical Education

Methods:

The study involved 56 people aged 62 to 71 years. Of them are 18 women, 38 men. 10 volunteers appropriate age category without ophthalmic pathology average compose the control group (group 1). 46 patients had a diagnosis of ocular ischemic syndrome (2-group). This diagnosis was based on the sharp disturbance of hemodynamic parameters in the ophthalmic artery. All patients underwent a comprehensive eye examination including visiometry, tonometry, computerized perimetry, gonioscopy, biomicroscopy, fundus ophthalmoscopy. Of special methods of investigation conducted optical coherence tomography (OCT), ultrasound color Doppler of ocular, transcranial and brachiocephalic vessels. According to the testimony examined magnetic - resonance tractography. Patients were consulted cardiologist, neurologist and a vascular surgeon. Tractography was performed on magnetic - resonance imaging to the field strength of 1.5 Tesla GE (BRIVO-355/USA). For correcting motion artifacts used echo navigator. Number of slices - 96. They are oriented perpendicular to the line connecting the anterior and posterior commissure of the brain. Slice thickness - 2.3 mm gap between them - 0, the image field - 220 mm, repetition time (TR) - 6,599-8,280 ms, echo time (TE ) - 70 ms, the diffusion coefficient (L ) - 600 s/mm2. Research time about 9 minutes.

Results:

Among patients with OIS anterior ischemic neuropathy combined with cataract and primary open - angle glaucoma established in 15 patients, chronic ischemic neuropathy combined with primary open - angle glaucoma in 19 patients, central retinal artery occlusion combined with anterior ischemic neuropathy in 12 patients. In the control group (healthy person) visual acuity was 6/7,5. In the main group with OIS visual acuity was 6/120. In the study of the field of vision in the main group MD averaged -11,43 ± 0,892 dB ( p <0,05), PSD average 10,25 ± 0,843 (p<0.05). In the control group the MD and PSD were within normal limits. MR tractography at normal levels observed in healthy control group and 16 patients of the main group. In 30 patients of the group observed the following changes: thinning fibers large occipital forceps - 8 patients, a partial tear of the upper row of fibers in place of attachment to the right optic radiation beam - at 8, partial visualization medial fibers of the optic beam - at 4, their intermittency - at 2, thinning of lateral right optic fiber beam - at 4, their differentiation in small amounts observed in 4 patients.

Conclusions:

The tractography in patients with OIS evidence of lesion of the optic tract with a significant decrease in visual functions. Thinning of the optic tract fibers serve as the basis for neuroprotective therapy. FINANCIAL INTEREST: NONE

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