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Short-term intraocular pressure changes after intravitreal applications: relationship with anterior chamber depth

Poster Details

First Author: E.Kurt TURKEY

Co Author(s):    G. Irey   G. Seymenoglu   H. Mayalı   S. Kılıç     

Abstract Details



Purpose:

To evaluate the short-term impact of intravitreal injection on IOP and ACD and to assess whether there is any correlation between IOP and ACD.

Setting:

One hundred and eighteen eyes of 105 patients who were administered intravitreal ranibizumab for wet age-related macular degeneration, diabetic macular edema, macular edema secondary to venous occlusion at Celal Bayar University Hafsa Sultan Hospital, Department of Ophthalmology Retina unit.

Methods:

One hundred and eighteen eyes of 105 patients who were administered intravitreal ranibizumab for wet age-related macular degeneration, diabetic macular edema, macular edema secondary to venous occlusion. All patients were examined by optical coherence tomography, fundus flourescein angiography for macular edema. Intraocular pressure of patients were measured immediately before intravitreal injections with Tono-Pen Avia (Reichert) contact tonometer. Anterior chamber depth and axial length of patients were measured immediately before intravitreal injections with Lenstar LS 900 (Haag Streit). Intraocular pressure, anterior chamber depth and axial length of patients were measured 5, 15, 30 minutes and first day after the intravitreal injection.

Results:

Patients were classified three distinct groups according to the axial length (AU) of the eyes (AU<22 mm, AU 22-24 mm, AU>24 mm). Patients were classified three distinct groups according to anterior chamber depths (ACD) of the eyes (ACD<2,5 mm, ACD 2,5-3,5 mm, ACD> 3,5 mm). Five minutes after the injection, mean IOP increased 24.15 ± 10.12 mmHg from 15.03 ± 2.86 mmHg and the difference was statistically significant (p<0,05). Fifteen minutes after the injection, mean IOP was 17.02 ± 5.25 mmHg, compared with baseline values the difference was statistically significant (p<0,05). Thirty minutes after the injection, IOP returned to baseline values. Five minutes after the injection, mean ACD decreased 2,90 ± 0,84 mm from 2,9498 ± 0,8957 mm and the difference was statistically significant (p<0,05).

Conclusions:

Intravitreal injection causes a considerable short-term transient rise in IOP. IOP rises correlated with shallow ACD, over time IOP decreases and ACD deepens. In our study, IOP increases returned to baseline values at 30 minutes after injection . On the basis of these findings, patients should be carefully monitored for at least 30 minutes after intravitreal injection FINANCIAL INTEREST: NONE

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