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Correlations among various ocular parameters in clinically unilateral pseudoexfoliation patients

Poster Details

First Author: B.Izgi TURKEY

Co Author(s):    S. Bayraktar   S. Cagman           

Abstract Details



Purpose:

To determine the correlations among various ocular parameters in clinically unilateral pseudoexfoliation(PEX) syndrome patients.

Setting:

Istanbul University, Istanbul Medical Faculty, Department of Ophthalmology, Glaucoma Unit

Methods:

The study includes subjects diagnosed with unilateral PEX syndrome by slit-lamp biomicroscopy between January and March 2014. The patients had no history of ocular surgery or laser therapy.The criteria also included subjects who had all of the following information and measurement parameters recorded at the same day. 1. Best-corrected visual acuity (BCVA); 2. the number of antiglaucoma medications; 3. Goldmann applanation tonometry for IOP; 4. mean deviation (MD) of SITA-standard central 30-2 program using the Humphrey Visual Field Analyzer; 5. spherical equivalent 6. corneal endothelial cell density, 7. central corneal thickness (CCT), 8.anterior chamber depth (ACD) and anterior chamber volume (ACV) using the Pentacam, 9. anterior chamber flare 10. c/d ratio obtained by HRT, 11. Avarege of retinal nerve fiber layer(RNFL) thickness obtained by SD-OCT. Paired Sample t test was used for the statistical analyses.

Results:

31 patients had PEX syndrome. 11 of them were excluded because of previous surgeries and the study included 40 eyes of 20 patients (11 men and 9 women). Mean age of the patients was 67.65±6.81 years. Compared to PEX-negative eyes, PEX- positive eyes had lower VA, higher IOP, worse visual field MD, lower ACV, higher flare value, higher c/d ratios, thinner avarage RNFL and required more antiglaucoma medications. ACD, BCVA and CCT did not differ statistically between the two groups. Endothelial cell density was lower in the pex-positive eyes but it was not significant statistically.

Conclusions:

These are the early results of an ongoing study. Our hypothesis is that correlation between IOP and ACV or flare and CECD suggests that glaucoma, keratopathy and breakdown of the blood - aqueous barrier occur in parallel with the progression of PEX. FINANCIAL INTEREST: NONE

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