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Risk factors and target intraocular pressure in primary open-angle glaucoma

Poster Details

First Author: V.Fokin RUSSIA

Co Author(s):    A. Schava   S. Balalin           

Abstract Details



Purpose:

to study whether age, blood pressure, glaucoma stage, corneal thickness and anterior-posterior ocular globe size have impact on level of target pressure in patients with primary open-angle glaucoma viewed from a perspective of tolerant pressure.

Setting:

The S.N. Fyodorov Eye Microsurgery Federal State Institution Volgograd branch

Methods:

there were examined 1310 patients (1638 eyes) with primary open-angle glaucoma and 365 healthy persons (640 eyes). We studied relationship between tolerant intraocular pressure and target pressure with consideration to risk factors of glaucoma progression.

Results:

mean value of true tolerant IOP in glaucoma patients equaled 16,5±0,1 mm Hg, which exceeds mean value of individual pressure in healthy persons by 2,5 mm Hg (P<0,001). Multivariative analysis made it possible to find the relationship between tolerant IOP, patient's age, diastolic blood pressure, central corneal thickness (CCT), anterior-posterior ocular globe size (APS) in patients with initial glaucoma stage: P0 tl = 19,6+0,056*diast. BP - 0,015*Age - 0,78*APS+0,021 CCT. Primary open-angle glaucoma progression induced decrease of tolerant pressure: on average by 0,3 mm Hg with every primary open-angle glaucoma stage.

Conclusions:

decrease of tolerant IOP in patients with primary open-angle glaucoma is registered in dependence with patient's ageing, growth of anterior-posterior ocular globe size (APS), lowering of blood pressure, decrement of central corneal thickness and glaucoma progression. FINANCIAL INTEREST: NONE

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