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Initial laboratory evaluation of a novel technique: flap-less, femtosecond laser-assisted myopic refractive lens extraction, stabilized with high-fluence CXL

Poster Details

First Author: A.Kanellopoulos GREECE

Co Author(s):    G. Asimellis   I. Kontari           

Abstract Details


To evaluate feasibility of ex-vivo femto-second laser-assisted intra-lamellar refractive lens extraction (ReLeX) using a novel technique with an alternative femtosecond-laser.

Setting: Eye Institute, Athens, Greece


Two-surface intra-lamellar bed corneal dissections were performed within a 5.5 mm optical zone. Lower. The FS200 femtosecond laser (Alcon/WaveLight, Erlangen, Germany) was employed in the study involving cadaver corneas. The lenticule was extracted through a 3.5 mm wide superior canal. High-fluence CXL was conducted in the pocket created. Pre- and post-operative total and lenticule thickness were measured by means of anterior-segment optical coherence tomography. Pre and post-operative corneal curvature was investigated via Scheimpflug imaging. Maximum (central) corneal thickness differences were compared to Munnerlyn formula predictions.


Lenticule creation and secondary extraction through the superior canal was efficient when employing the FS200 laser. Lenticule thickness studied was that of 50 μm. OCT-derived corneal thickness differences, as well as Scheimpflug imaging-derived topographic differences were consistent with a myopic change. Both modalities highlighted the interlamellar CXL effect.


This ex-vivo laboratory study confirms the FS200 femtosecond laser refractive lens extraction capability for correcting myopia. In-pocket adjunct cross-linking may facilitate, stabilize the postoperative recovery, and potentially be employed to induce asphericity and correct small residual spherocylindrical refractive errors. FINANCIAL INTEREST: One of more of the authors... travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented

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