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The assessment of levofloxacin and moxifloxacin eye drop concentrations in anterior chamber aqueous humor by HPLC-MS method

Poster Details

First Author: I.Okolov RUSSIA

Co Author(s):    Y. Takhtaev   A. Myazhitova           

Abstract Details



Purpose:

To determine the concentration of Signicef, Oftaquix and Vigamox eye drops in anterior chamber aqueous humor.

Setting:

S. Fyodorov IR&TC 'Eye Microsurgery', St.-Petersburg, Russian Federation

Methods:

90 patients were included in the study. In group I (30 patients), moxifloxacin (Vigamox) was used, in group II (30 patients) and group III (30 patients), 0.5% levofloxacin was used (Oftaquix and Signicef, respectively). Antibacterial eye drops were instilled for an hour before surgery every 15 min (i.e., 4 times) in all subjects. Antibacterial medications concentrations in anterior chamber aqueous humor were measured by HPLC-MS/MS method.

Results:

Mean concentrations of Oftaquix and Vigamox eye drops in anterior chamber aqueous humor were 0.9 μς /mL and 1.0 μς /ml, respectively, while Signicef mean concentration was 1.5 μς/ml.

Conclusions:

Mean concentrations of all tested drugs that belong to a group of fluoroquinolones were several times higher as compared with mean MIC90 for strains isolated from patients. This provides safe post-op period and infectious complications prevention. FINANCIAL INTEREST: NONE

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