London 2014 Registration Visa Letters Programme Satellite Meetings Glaucoma Day 2014 Exhibition Hotel Booking Virtual Exhibition Star Alliance
london escrs

Course handouts are now available
Click here

Come to London


WATCH to find out why

Site updates:

Programme Updates. Programme Overview and - Video Symposium on Challenging Cases now available.


Search Abstracts by author or title
(results will display both Free Papers & Poster)

The assessment of levofloxacin and moxifloxacin eye drop concentrations in anterior chamber aqueous humor by HPLC-MS method

Poster Details

First Author: I.Okolov RUSSIA

Co Author(s):    Y. Takhtaev   A. Myazhitova           

Abstract Details


To determine the concentration of Signicef, Oftaquix and Vigamox eye drops in anterior chamber aqueous humor.


S. Fyodorov IR&TC 'Eye Microsurgery', St.-Petersburg, Russian Federation


90 patients were included in the study. In group I (30 patients), moxifloxacin (Vigamox) was used, in group II (30 patients) and group III (30 patients), 0.5% levofloxacin was used (Oftaquix and Signicef, respectively). Antibacterial eye drops were instilled for an hour before surgery every 15 min (i.e., 4 times) in all subjects. Antibacterial medications concentrations in anterior chamber aqueous humor were measured by HPLC-MS/MS method.


Mean concentrations of Oftaquix and Vigamox eye drops in anterior chamber aqueous humor were 0.9 μς /mL and 1.0 μς /ml, respectively, while Signicef mean concentration was 1.5 μς/ml.


Mean concentrations of all tested drugs that belong to a group of fluoroquinolones were several times higher as compared with mean MIC90 for strains isolated from patients. This provides safe post-op period and infectious complications prevention. FINANCIAL INTEREST: NONE

Back to Poster listing