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Corneal stromal demarcation line determined with anterior segment optical coherence tomography following standard and a modified accelerated corneal collagen cross-linking protocol

Poster Details

First Author: K.Tsoulnaras GREECE

Co Author(s):    M. Grentzelos   D. Liakopoulos   N. Tsakalis   G. Kymionis     

Abstract Details


To compare the corneal stromal demarcation line depth using anterior segment optical coherence tomography (AS-OCT) after corneal collagen cross-linking (CXL) using two different treatment protocols: the standard Dresden protocol (30 minutes with 3mW/cm2) and a modified accelerated protocol (14 minutes with 9mW/cm2).


Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete, Greece


43 keratoconic patients (52 eyes) were enrolled. All patients underwent CXL using the same high-intensity ultraviolet-A (UV-A) irradiation device (CCL-365, Peschke Meditrade GmbH, Huenenberg, Switzerland). 26 eyes were treated for 30 minutes with 3mW/cm2 according to the standard Dresden protocol (group 1), while 26 eyes were treated with a novel modified accelerated CXL protocol for 14 minutes with 9mW/cm2 of UV-A irradiation intensity (group 2). One month postoperatively, corneal stromal demarcation line was measured by two independent observers using AS-OCT.


Corneal stromal demarcation line depth was assessed with no significant difference between observer measurements for both groups (p = 0.676 for group 1 and p = 0.566 for group 2). Mean corneal stromal demarcation line depth was 337.00 ± 46.46 μm for group 1 and 322.91 ± 48.28 μm for group 2. There was no statistically significant difference (p = 0.243) in the corneal stromal demarcation line depth between the two groups.


Corneal stromal demarcation line depth after 30-minutes with 3mW/cm2 and 14-minutes with 9mW/cm2 CXL treatment was similar. Modified accelerated protocol of 14-minutes CXL provided the same treatment depth as the classic Dresden protocol. FINANCIAL INTEREST: NONE

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