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Accelerated versus conventional corneal collagen cross-linking in progressive keratoconus: does faster work better?

Poster Details

First Author: H.Hasani IRAN

Co Author(s):    M. Sadoughi   B. Einollahi   R. Shamsoddinimotlagh        

Abstract Details


To compare outcomes of accelerated and conventional corneal cross-linking (CXL) for progressive keratoconus.


Prospective comparative randomized clinical trial study. Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences.


In this ongoing randomized clinical trial study, sixty eyes of thirty patients (18 male and 12 female) who had a minimum follow-up of 12 months were enrolled in study. Eligible patients randomly received conventional(3mW/cm2 for 30min) CXL in one eye or accelerated (18mW/cm2,5min) CXL in the fellow eye.Main Outcome Measures were:UDVA, CDVA, keratometric values,endothelial cell count. Secondary outcome measures were: CRF (corneal resistance factor), CH(corneal hysteresis),CCT (central corneal thickness).


Changes in UDVA and CDVA was statistically significant in the conventional (p = 0.03) and accelerated CXL group(p = 0.04). It did not reach statistical significance between the conventional and accelerated CXL group = 0.11 and p = 0.12, respectively). . The decrease in the mean corneal power (Kmin) and maximum keratometric value (Kmax) were statistically significant in the accelerated CXL group (p = 0.02) and conventional CXL group (p= 0.03).There was no statistically significant difference in UDVA(p=0.61), CDVA (p=0.52), Kmax change(p=0.11), Kmin change(p=0.43) between the two groups. The mean decrease of CH (p=0.33), CRF (p=0.92), CCT (p=0.061) and ECC(p=0.08)was similar in both groups.


Refractive and visual results, biomechanics and central corneal thickness changes are comparable in accelerated and conventional CXL methods.Endothelial cell loss is also similar in both group. FINANCIAL INTEREST: NONE

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