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Accelerated versus conventional corneal collagen cross-linking in progressive keratoconus: does faster work better?

Poster Details

First Author: H.Hasani IRAN

Co Author(s):    M. Sadoughi   B. Einollahi   R. Shamsoddinimotlagh        

Abstract Details



Purpose:

To compare outcomes of accelerated and conventional corneal cross-linking (CXL) for progressive keratoconus.

Setting:

Prospective comparative randomized clinical trial study. Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences.

Methods:

In this ongoing randomized clinical trial study, sixty eyes of thirty patients (18 male and 12 female) who had a minimum follow-up of 12 months were enrolled in study. Eligible patients randomly received conventional(3mW/cm2 for 30min) CXL in one eye or accelerated (18mW/cm2,5min) CXL in the fellow eye.Main Outcome Measures were:UDVA, CDVA, keratometric values,endothelial cell count. Secondary outcome measures were: CRF (corneal resistance factor), CH(corneal hysteresis),CCT (central corneal thickness).

Results:

Changes in UDVA and CDVA was statistically significant in the conventional (p = 0.03) and accelerated CXL group(p = 0.04). It did not reach statistical significance between the conventional and accelerated CXL group = 0.11 and p = 0.12, respectively). . The decrease in the mean corneal power (Kmin) and maximum keratometric value (Kmax) were statistically significant in the accelerated CXL group (p = 0.02) and conventional CXL group (p= 0.03).There was no statistically significant difference in UDVA(p=0.61), CDVA (p=0.52), Kmax change(p=0.11), Kmin change(p=0.43) between the two groups. The mean decrease of CH (p=0.33), CRF (p=0.92), CCT (p=0.061) and ECC(p=0.08)was similar in both groups.

Conclusions:

Refractive and visual results, biomechanics and central corneal thickness changes are comparable in accelerated and conventional CXL methods.Endothelial cell loss is also similar in both group. FINANCIAL INTEREST: NONE

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