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Correlation of the corneal collagen cross-linking demarcation line using confocal microscopy and anterior segment optical coherence tomography in keratoconic patients

Poster Details

First Author: M.Grentzelos GREECE

Co Author(s):    A. Plaka   K. Tsoulnaras   V. Diakonis   D. Liakopoulos   A. Pallikaris   G. Kymionis

Abstract Details


To evaluate and compare the depth of the corneal stromal demarcation line after corneal collagen cross-linking (CXL) using two different methods: confocal microscopy and anterior segment optical coherence tomography (AS-OCT).


Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete, Greece


In this prospective, comparative, interventional case series, 17 patients (18 eyes) with progressive keratoconus were enrolled. All patients underwent uneventful CXL treatment. One month postoperatively, corneal stromal demarcation line depth was measured in all patients by two independent observers using confocal microscopy and AS-OCT.


Mean corneal stromal demarcation line depth measured using confocal microscopy by the first observer was 306.22 ± 51.54 μm (245-417 μm) and by the second observer was 303.5 ± 46.98 μm (240-390 μm). The same measurements using AS-OCT were 300.67 ± 41.56 μm (240-385 μm) and 295.72 ± 41.01 μm (228 - 380μm) for the first and second observer, respectively. There was no statistically significant difference between confocal microscopy and AS-OCT measurements for both observers (p=0.3219 for the first and p=0.1731 for the second observer).


Both confocal microscopy and AS-OCT have similar results in evaluating the depth of the corneal stromal demarcation line after CXL. Therefore, the noninvasive technology of AS-OCT may be used in the future as a simple and effective clinical method to evaluate the effectiveness of CXL treatment. FINANCIAL INTEREST: NONE

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