London 2014 Registration Visa Letters Programme Satellite Meetings Glaucoma Day 2014 Exhibition Hotel Booking Virtual Exhibition Star Alliance
london escrs

Course handouts are now available
Click here


Come to London

video-icon

WATCH to find out why


Site updates:

Programme Updates. Programme Overview and - Video Symposium on Challenging Cases now available.


Posters

Search Abstracts by author or title
(results will display both Free Papers & Poster)

Rapid corneal collagen cross-linking for progressive corneal ectasia: 12 month results

Poster Details

First Author: D.Gore UK

Co Author(s):    M. Nicholae   N. Kopsachilis   M. Malandrakis   B. Allan     

Abstract Details



Purpose:

To report 12-month results of rapid corneal collagen cross-linking (CXL) in progressive ectasia.

Setting:

Moorfields Eye Hospital

Methods:

Design: Retrospective, uncontrolled case series. Serial corneal Scheimpflug tomography and subjective refractions were used to confirm pre-operative ectasia progression, defined by one or more of the following: >1.5 dioptre (D) increase in Kmax; >1.5D increase in anterior K2; >0.5D increase in posterior K2; >1D increase in refractive astigmatism; >1 line loss of corrected distance visual acuity (CDVA), > 13µm decrease in central or thinnest pachymetry. Patients with active ocular surface disease and those with a minimum corneal thickness <375 µm were excluded. Following manual epithelial debridement, the cornea was soaked in riboflavin 0.1% in HPMC for either 20 minutes (if minimum pachymetry ≥400µm) or 10 minutes (if minimum pachymetry <400µm). Continuous UVA exposure at 30mW/cm2 for 4 minutes was used in all eyes (total energy 7.2mJ/cm2). The primary outcome measure was the change in Kmax at 12 months. Treatment failure was defined by an increased in Kmax of >1.5D at 12 months.

Results:

Rapid CXL was performed on 33 eyes of 30 patients (32 keratoconus, 1 post-LASIK ectasia; mean age 27 years). At 12 months, the mean (± standard deviation) change in Kmax was -0.45 ± 2.36D (p=0.29). 4 (12%) of 33 eyes were still progressing, with a mean increase in Kmax of 2.7 ± 1.1D. Manifest cylinder remained unchanged (mean -0.1 ± 2.7D, p=0.88). One (3%) eye lost more than 2 lines of CDVA. One (3%) sterile infiltrate developed which responded rapidly to additional topical steroids. No infective complications occurred.

Conclusions:

Effective stabilisation of progressive ectasia was observed at 12 months following rapid CXL in 88% of treated eyes. FINANCIAL INTEREST: NONE

Back to Poster listing