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Rapid corneal collagen cross-linking for progressive corneal ectasia: 12 month results

Poster Details

First Author: D.Gore UK

Co Author(s):    M. Nicholae   N. Kopsachilis   M. Malandrakis   B. Allan     

Abstract Details


To report 12-month results of rapid corneal collagen cross-linking (CXL) in progressive ectasia.


Moorfields Eye Hospital


Design: Retrospective, uncontrolled case series. Serial corneal Scheimpflug tomography and subjective refractions were used to confirm pre-operative ectasia progression, defined by one or more of the following: >1.5 dioptre (D) increase in Kmax; >1.5D increase in anterior K2; >0.5D increase in posterior K2; >1D increase in refractive astigmatism; >1 line loss of corrected distance visual acuity (CDVA), > 13µm decrease in central or thinnest pachymetry. Patients with active ocular surface disease and those with a minimum corneal thickness <375 µm were excluded. Following manual epithelial debridement, the cornea was soaked in riboflavin 0.1% in HPMC for either 20 minutes (if minimum pachymetry ≥400µm) or 10 minutes (if minimum pachymetry <400µm). Continuous UVA exposure at 30mW/cm2 for 4 minutes was used in all eyes (total energy 7.2mJ/cm2). The primary outcome measure was the change in Kmax at 12 months. Treatment failure was defined by an increased in Kmax of >1.5D at 12 months.


Rapid CXL was performed on 33 eyes of 30 patients (32 keratoconus, 1 post-LASIK ectasia; mean age 27 years). At 12 months, the mean (± standard deviation) change in Kmax was -0.45 ± 2.36D (p=0.29). 4 (12%) of 33 eyes were still progressing, with a mean increase in Kmax of 2.7 ± 1.1D. Manifest cylinder remained unchanged (mean -0.1 ± 2.7D, p=0.88). One (3%) eye lost more than 2 lines of CDVA. One (3%) sterile infiltrate developed which responded rapidly to additional topical steroids. No infective complications occurred.


Effective stabilisation of progressive ectasia was observed at 12 months following rapid CXL in 88% of treated eyes. FINANCIAL INTEREST: NONE

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