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Determining efficacy of high intensity CXL outcomes for the treatment of keratoconus: Kmax or surface height indices?

Poster Details

First Author: A.Cummings IRELAND

Co Author(s):    R. McQuaid              

Abstract Details


This study had 2 purposes: 1) Determine the safety and efficacy of the IROC UV-X 2000 device with which accelerated cross-linking (AXL) is performed over 10 minutes. 2) Track K-Max, ISV (Index of Surface Variance) and IHD (Index of Height Decentration) to determine if there is any correlation between these indices and the current standard K-Max


Wellington Eye Clinic, Dublin, Ireland. 2 surgeons.


33 eyes were treated with higher intensity AXL (10mW/cm²) in a prospective study. To date, 21 eyes have one year follow up. Maximum keratometry results were compared to IHD and ISV on each visit post-operatively using the Allegro Oculyzer, and Allegro Topolyzer (Wavelight AG).


Results reveal 21 eyes treated with AXL (10mW/cm²) show an average reduction of 2.33 Diopters in maximum keratometry (K-Max) 1 year post operatively. ISV values show an excellent correlation with K-Max at 6 months and 1 year post operatively while IHD appears to have a poor correlation to the other 2 parameters.


To date, the Wellington Eye Clinic has monitored the progression or regression of keratoconus pre- and post CXL using maximum keratometry (K-Max). We explored corneal changes post high intensity CXL using ISV values and found a reduction correlating to K-max readings. IHD had a poor correlation with K-Max and ISV. These results indicate that the ISV may be a useful additional parameter to use when monitoring keratoconus or the effects of CXL. AXL was proven to be safe and effective with the IROC UV-X 2000 device. FINANCIAL INTEREST: NONE

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