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Multicenter trial on Descemet's membrane endothelial keratoplasty (DMEK): first case series of 18 surgeons

Poster Details

First Author: M.Dirisamer AUSTRIA

Co Author(s):    C. Monnereau   R. Quilendrino   I. Dapena   G. Melles     

Abstract Details



Purpose:

To document the clinical outcome of standardized ‘no-touch' Descemet membrane endothelial keratoplasty (DMEK) and its complications during the learning curve of experienced surgeons.

Setting:

Netherlands Institute for Innovative Ocular Surgery / Tertiary referral center

Methods:

By 18 different surgeons in 11 countries, DMEK was performed for Fuchs endothelial dystrophy (68%), and bullous keratopathy (32%) in a total of 431 eyes of 401 patients. Best corrected visual acuity (BCVA), endothelial cell density and intra- and postoperative complications were recorded.

Results:

Overall, BCVA improved in 258 eyes (94%), remained unchanged in 12 eyes (4%), and deteriorated in 5 eyes (2%). Visual acuity data up to 6 months were pooled (n=275) and showed that 217 eyes (79%) reached a BCVA of ≥20/40 (≥0.5), 117 eyes (43%) ≥20/25 (≥0.8), and 61 (22%) ≥20/20 (≥1.0). Eyes with ≥6 months follow-up (n=176) reached similar BCVA outcomes. Average decrease in endothelial cell density at 6 months was 47% (n=133). Intraoperative complications were rare, including difficulties in inserting, unfolding or positioning of the graft (1%) and intraoperative hemorrhage (0.5%). The main postoperative complication was graft detachment (35%); 20% underwent a single rebubbling procedure, occasionally requiring a second or third rebubbling (3% and 1%, respectively), and 18% underwent a secondary keratoplasty.

Conclusions:

Our multicenter study showed that the standardized ‘no-touch' DMEK technique was feasible in most hands. The main challenges for surgeons starting out with the procedure, may be (1) to decide whether graft preparation is outsourced or performed during surgery; (2) to limit the number of graft detachments and secondary procedures; and (3) to obtain organ cultured donor corneal tissue. FINANCIAL INTEREST: One of more of the authors... receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented

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