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Five-year graft survival comparing Descemet's stripping automated endothelial keratoplasty with penetrating keratoplasty in an Asian cohort

Poster Details

First Author: M.Ang SINGAPORE

Co Author(s):    J. Mehta   D. Tan           

Abstract Details


To compare 5-year graft survival following Descemet's stripping automated endothelial keratoplasty (DSAEK) and conventional penetrating keratoplasty (PK) in Asian eyes.


Tertiary Center


We reviewed consecutive patients who underwent DSAEK (60 eyes) or PK (128 eyes) with Fuchs' endothelial dystrophy (FED) or bullous keratopathy (BK) from 2006 - 2008, with a minimum of 5-year clinical follow-up. Clinical data, donor and recipient characteristics were recorded from our prospective Singapore Corneal Transplant Study. All surgeries were performed by the 5 corneal surgeons at our centre, which included cases performed or partially performed by corneal fellows in training under direct supervision. Our main outcome measure was cumulative graft survival up to 5 years.


There were no significant differences in baseline characteristics of patients who underwent either DSAEK or PK. There was no difference in proportion of primary diagnosis (FED: 111 eyes, 59% versus BK: 77 eyes, 41%) between surgical techniques (P=0.855). Overall 5-year graft survival was comparable between DSAEK and PK (86.9% vs. 85.3%, log-rank P value = 0.199). Median 5-year endothelial cell loss was significantly greater in PK compared to DSAEK (71.7% vs. 46.9%, P<0.001). Graft survival was superior in DSAEK compared to PK in FED eyes (100% vs. 89.3%) but not in PBK eyes (82.7% vs. 80.0%, log-rank P value = 0.321).


In Asian eyes from the same study cohort with a standard post-operative regime, 5-year graft survival was comparable between DSAEK and PK in eyes with FED and BK. FINANCIAL INTEREST: One of more of the authors... gains financially from product or procedure presented

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