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Descemet's stripping endothelial keratoplasty (DSEK): early and late complication rates in 73 consecutive cases at a tertiary university hospital

Poster Details

First Author: N.Abdul Aziz UK

Co Author(s):    M. Rashid   P. Hossain           

Abstract Details


The purpose of this study is to describe the outcome and complications of DSEK surgery using manually dissected donor tissue at a tertiary university referral centre.


University Hospital of Southampton NHS Trust, Southampton Eye Unit, Mailpoint 104, Tremona Road, Southampton, Hants, SO16 6YD


A retrospective, consecutive case review of 100 eyes between 2007 and 2013. Main outcome measures included best corrected distance visual acuity (BDVA), post-operative manifest refractive spherical equivalence (MRSE), IOP elevation, and posterior graft dislocation, graft rejection, primary graft failure, and graft survival rates at 24 months.


The median age at the time of surgery was 74 years (LQ 65, UQ 80, range 37-92). Surgical indications included Fuch's dystrophy (64.4%), bullous keratopathy (34.3%) and other (1.4%). Sixty-six percent were pseudophakic and 34% were phakic eyes. Eighty-four percent had DSEK alone, 6% had repeat DSEK and 10% received a triple procedure. Raised IOP was the main complication (21.9%), followed by posterior graft dislocation (15.1%), graft rejection (6.8%) and primary graft failure (6.8%). Median LogMAR BDVA was 0.52 (LQ 0.36, UQ 0.75, range 0.12-1.90) and 0.40 (LQ 0.34, UQ 0.7, range 0.12-1.90) at 12 and 24 months, respectively. The average post-operative MRSE at last review was 0.5±1.4 D. Rate of graft survival at 24 months was 82%.


The main complication observed at our centre was raised IOP. Posterior graft dislocation, graft rejection and primary graft failure rates were comparable to those reported elsewhere in the peer-reviewed literature. FINANCIAL INTEREST: NONE

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