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Topical treatment of blood staining cornea with desferrioxamine

Poster Details

First Author: F.Wang CHINA

Co Author(s):    Y. Wang   L. Li   B. Ren        

Abstract Details



Purpose:

To evaluate the clinical outcome of drug therapeutic approach of defessrioxamine in blood staining cornea with a case report.

Setting:

Department of Ophthalmology, China-Japan Union Hospital of Jilin University, China

Methods:

A 45-year-old male was referred to our hospital for unilateral ocular complaints. The presenting symptoms was asymptomatically progressive brown cornea, following decreased vision in his right eye for six months duration. The patient's family, medical history were noncontributory, but cataract surgery was performed in his childhood. On ocular examination, the UCVA was no light perception in the right eye, IOP was over 40 mmHg. The clinical signs include fine yellow granules in the posterior corneal stroma, yellow discoloration of the stroma. The rest intraocular structure could not be checked. Posterior segment showed vitreous hemorrhage detected with B-Scan ocular ultrasound. Diagnosed as corneal blood staining. The patient refused to accept penetrating keratoplasty and cosmetic contact lens therapy. Desferrioxamine was diluted to 10% solution, subconjunctival injection of 50mg was given every other day for 2 weeks, and prescribed desferrioxamine as eyedrops three times a day. Thereafter subconjunctival injection of 100mg every other 3 more weeks.

Results:

The apperance of eye was significantly improved, clearance of the blood staining began peripherally and progressed centrally. IOP elevation was also released. The patient was followed up to 6 months, IOP remained normal range, the rest part of eye had no any further progressive sign.

Conclusions:

Management in patient with remote blood staining of cornea can be difficult. It is reported that there is no significant difference in efficacy between surgical and medical removal. The combination of the eyedrops and subconjunctival injection method supposed to be useful for promoting the clearance of corneal blood staining. Alternative therapy is a beneficial choice for many cases that require penetrating keratoplasty. Further observation are required to determine the most-appropriate management. FINANCIAL INTEREST: NONE

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