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Central corneal thickness in anirdics and relatives: a pilot study

Poster Details

First Author: J.Paz Moreno-Arrones SPAIN

Co Author(s):    A. Rodero Sanchez   F. Aviles Rogel   M. Teus Guezala        

Abstract Details



Purpose:

To compare central corneal thickness (CCT) measured by ultrasound cornal pachymetry (US) and intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT) in patients suffering from congenital aniridia and in first-degree relatives not affected.

Setting:

Clinicas Novovision, Madrid.

Methods:

We designed a transversal and observacional study. We performed five measurements of CCT by US and three IOP measurements by GAT in 16 eyes suffering from congenital aniridia with no glaucoma nor remarkable corneal pathology and in also in healthy 14-eyes of parents and 10-eyes of brothers. We used an ANOVA test as statistical analysis.

Results:

Average CCT in anirIdic group was of 651,81±50,40 µm, whereas in aniridia parents group was of 588,07 ±29,58 µm and 576±47,92 µm in aniridia brothers group (P <0.0001). GAT in affected eyes was 15,25±2,01 mmHg, 15,64±2.43 mmHg in parents and of 16,1±1,52 mmHg in brothers (P <0.5).

Conclusions:

Patients suffering from congenital aniridia develop thicker CCT than general population included first-degree relatives. In addition, IOP in this scenario seems to be significantly overestimated in this patients and relatives. This finding might be intimately related to the gene PAX6, that codifies for aniridia. Moreover, a thicker ultrasound pachymetry in first-degree relatives could be a diagnosis of a form fruste aniridia in not symptomatic population. FINANCIAL INTEREST: NONE

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