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The efficacy of diquafosol tetrasodium and cyclosporine A in patients

Poster Details

First Author: K.Kim SOUTH KOREA

Co Author(s):                  

Abstract Details


To evaluate the efficacy of topical diquafosol tetrasodium and topical cyclosporine A for dry eye


prospective randomized comparative analysis


This study was performed in 30 patients (30 eyes) with dry eye level 1, 2. Fifteen patients (group 1) were treated with Diquafosol tetrasodium 3%(Diquas) and 15 patients (groups 2) used topical cyclosporine A 0.05%. Before treatment and at 2, 4 weeks tear film BUT, Shirmer, cornea and conjunctival stain, tear meniscus parameters at OCT were measured. Subjective symptom were asked with OSDI questionnaire.


Both treatments led to improvement in the tBUT, cornea and conjunctival stain, tear meniscus parameters at OCT and symptom score. Group 1 showed a little faster improvement at 2 weeks than group 2 but there isn't significant difference at 4 weeks. Shirmer score didn't show significant improvement at both groups. One patient in group 2 stop using eyedrop because of irritation.


Diquafosol tetrasodium and topical cyclosporine were effective and safe in treating mild to moderate dry eye. Relatively Diquafosol tetrasodium showed better compliance and faster effect than topical cyclosporine A at 2 weeks. FINANCIAL INTEREST: NONE

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