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Novel KCN diagnosis and progression criteria, based on multiple anteriorsegment imaging devices

Poster Details

First Author: G.Asimellis GREECE

Co Author(s):    A. Kanellopoulos   C. Karabatsas           

Abstract Details


To evaluate Keratoconus Diagnosis and Progression Assessment based on modern anterior segment imaging modalities including Scheimpflug imaging, Placido Topography, Anterior-Segment Optical Coherence Tomography (AS-OCT), and novel Multi-colored Spot Reflection Topography (MSRT).

Setting: Eye Institute, Athens, Greece


Two hundred fifty keratoconic cases were evaluated for keratoconic grading and anterior surface indexing by Scheimpflug imaging (Oculyzer , WaveLight AG, Erlagen, Germany), Placido Topography (Vario Topolyzer, WaveLight AG), AS-OCT (RTVue-100, Optovue Inc., Fremont, CA) and a newly-introduced MSRT (Cassini, i-Optics, the Hague, The Netherlands). The correlations between Scheimpflug- and Placido- derived keratoconic grading and anterior-surface irregularity indices for keratoconus, as well as epithelial thickness distribution characteristics were assessed with the AS-OCT and the MSRT-derived keratoconus indices employing paired two-tailed t-tests, Bland-Altman plots, coefficient of determination (r2), and trend line linearity.


Excellent agreement among the Scheimpflug- and Placido- derived keratoconic grading and anterior-surface irregularity indices for keratoconus with the AS-OCT and the MSRT - derived keratoconus was observed. Increased topographic thickness variability and range was found to be in correlation with keratoconus severity, quantitatively expressed with Scheimpflug imaging-derived anterior-surface irregularity indices.


The quantitative anterior-segment topographic indices may help aid in early diagnosis, proper monitoring and surgical follow-up in keratoconus by providing quantitative measure of ectasia progression. We present a benchmark for future studies for the development of keratoconus diagnosis, possibly providing an effective tool of post-operative cross-linking or other ectasia-management procedures monitoring FINANCIAL INTEREST: One of more of the authors... travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented

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