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A clinical case of Wegener granulomatosis with ocular involvement

Poster Details

First Author: R.Anjos PORTUGAL

Co Author(s):    L. Vieira   M. Lisboa   A. Cabugueira   V. Maduro   I. Domingues   P. Ferreira

Abstract Details


To describe a case of Wegener granulomatosis with ocular surface involvement.


Centro Hospitalar Lisboa Central


The authors present a case of an 82 year-old male with progressive visual loss, anorexia and asthenia. The patient had a history of glaucoma, renal insufficiency, chronic sinusitis and was being investigated for non-specific pulmonary lesions. Best corrected visual acuity was 6/10 at the right eye and 3/10 at the left eye. Biomicroscopy revealed bilateral peripheral ulcerative keratitis and bilateral scleromalacia in the temporal-inferior quadrants.


A complete blood work-up revealed anemia, elevated C-reactive protein (123,7 mg/L) and rheumatoid factor (138 UI/mL). CT-scans showed pulmonary nodular lesions with associated cavitation. A presumptive diagnosis of Wegener granulomatosis was established and treatment with systemic corticotherapy and cyclophosphamide was initiated with stabilization of the ocular and systemic manifestations.


Wegener granulomatosis is a rare disease that affects small and medium vessels. Although more frequently associated with pulmonary and renal changes, ocular involvement may occur in up to 50% of cases. The ophthalmologist evaluation may be critical to the diagnosis and monitorization of this disease FINANCIAL INTEREST: NONE

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